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‘Origami-inspired’ folding electrodes could reduce surgery needed to treat brain conditions

'Origami-inspired' folding electrodes could reduce surgery needed to treat brain conditions

A research team led by the University of Oxford and the University of Cambridge have created new ‘origami-inspired’ brain electrodes that can fold up to a fraction of their full size. This advance could significantly reduce the amount of surgery needed to treat conditions such as epilepsy, or to install brain-computer interfaces.

Measuring brain electrical activity is essential to accurately diagnose and treat conditions such as epilepsy. However, this often requires surgeons to cut out a large window in the skull (a craniotomy) to place electrodes directly onto the brain surface. This highly invasive procedure typically entails a prolonged recovery period, and poses severe infection risks.

The study, “Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography” published in Nature Communications, demonstrated that using a folding design for brain electrodes could reduce the incision area needed by about five times, without affecting functionality.

Senior author Associate Professor Christopher Proctor (Department of Engineering Science, University of Oxford) said, “This study presents a new approach to directly interfacing with large areas of the brain through a key-hole like surgery. The potential significance of this work is two-fold. First, there is the promise of a less invasive diagnostic tool for epilepsy patients. Second, we envision the minimally invasive nature will enable new applications in brain machine interfaces.”

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Illustration of the origami-inspired electrode array unfolding on the surface of the brain after minimally invasive surgical implantation. Credit: Massimo Mariello (University of Oxford)

When fully expanded, the device resembles a flat, rectangular silicone wafer with 32 embedded electrodes, attached to a cable. The wafer—around 70 microns thick (about the width of a human hair)—is then folded up, accordion-like, enabling it to fit through a slit just 6 mm across. Once in position on the brain surface, a pressurized fluid-filled chamber in the wafer inflates and unfolds the device to cover an area five times larger, up to 600 mm2.

In comparison, applying a non-folding device of the same size would typically require cutting out an area of at least 600 mm2 from the skull.

The researchers confirmed the device’s functionality by testing it on anesthetized pigs, using facilities at the Universities of Cambridge and Bologna. This demonstrated that the unfolded electrodes were able to accurately detect and record brain activity.

According to the team, the device could potentially start to be used to treat human patients within a few years. Around 50 million people worldwide have epilepsy, which carries a risk of premature death up to three times higher than for the general population (World Health Organization).

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Thin-film soft robotic electrode array designed for safer and less invasive epilepsy surgical mapping. Credit: Lawrence Coles (University of Cambridge)

Lead-author Dr. Lawrence Coles (Department of Engineering, University of Cambridge) said, “We are now working with clinical partners to refine the design with the aim of starting trials in human patients within two years. Besides epilepsy, this approach could be used to diagnose and treat other conditions that result in brain seizures, such as certain brain tumors.”

According to the researchers, the fold-up design could also reduce the amount of surgery needed to install brain-computer interfaces, which could benefit people with disabilities as well as optimize human-computer interactions.

“Brain-computer interfaces are an incredibly fast-moving and promising area of development,” Dr. Coles added. “A particularly exciting area is direct speech decoding, where electrodes measure signals directly off the brain surface itself to translate what the person is trying to say.”

Ley Sander, medical director at the Epilepsy Society and Professor of Neurology at UCL (who was not involved with the study) said, “This is an exciting new approach to brain surgery, but it is very much in its infancy. Anything that reduces the invasive nature of brain surgery and the risk of infection has to be welcomed, particularly if it promises a shorter recovery time.

“Brain surgery is only possible for people for whom we are able to pinpoint the area of the brain where their seizures occur, but in these cases, it offers real hope of seizure freedom.”

※Top Image: Origami-inspired soft robotic electrode array that can be deployed on the brain surface for minimally invasive surgical neural mapping. Credit: Lawrence Coles (University of Cambridge) 

This article was written by Medical Xpress from Medical Xpress and was legally licensed through the DiveMarketplace by Industry Dive. Please direct all licensing questions to legal@industrydive.com.